Effect Lap Lambert Academic Publishing Effect of Quercetin on Copper Sulphate Induced Proventriculitisin rats Paperback

Heavy metal toxicity, especially from copper sulfate, significantly affects poultry health byinducing conditions such as pro-ventriculitis, nephrotoxicity, and Cuproptosis in broiler chicks. These disorders lead to inflammation, oxidative stress, impaired organ function, poor growth, andreduced feed efficiency. Quercetin, a well-known plant flavonoid, possesses potent anti-inflammatory, antioxidant, hepatoprotective, and nephroprotective properties, making it apromising natural therapeutic agent. This study aimed to evaluate the protective effects ofquercetin against copper sulfate-induced toxicity in broiler chicks. Experimental groups receivedcopper sulfate to induce toxicity, followed by treatment with quercetin at two different doses (200mg/kg and 400 mg/kg), and probenecid (2.6 mg/kg) as a standard nephroprotective control. Histopathological evaluations of the proventriculus and kidneys were performed to assessinflammation and tissue damage. The results revealed that quercetin at 200 mg/kg provided superior anti-inflammatory andhepatoprotective effects compared to the higher dose. A biphasic response was obs.ed, wherethe 400 mg/kg dose potentially acted as a pro-oxidant.